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With a view to studying relationships between structure and pharmacological action more systematically it was decided to synthesise [various] series of nicotine analogues in [each of] which, as far as possible, only one part of the nicotine molecule at a time is changed. The commercial applications for neurologically active nicotine analogs that might have been in mind by the researchers and/or the sponsor may have included uses as: (1) substitutes for nicotine in consumer tobacco products

Outcomes typically revert back to baseline levels after the contingencies are removed, however, without other treatments to supplement the contingency management