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[10] Participants described the color of packaging as representing characteristics of the product, such as taste and strength

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It is the oldest form of tobacco smoking, pre-dating the use of the earliest pipes, and before the first machine- made cigarettes were manufactured

Studies carried out with smokers have confirmed these findings in animal models, showing alterations in the respiratory epithelium as an enlargement of the naked epithelium,25 a greater prevalence of hyperplasia and cell atypias26 and ultrastructural cilia abnormalities27