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Some of the mental and physical effects of depressants include: Mental side effects of depressants include: Confusion or disorientation Impaired cognition Impaired judgment Lowered reaction time Amnesia Physical side effects from abusing depressants include: Depressed, slowed, or irregular breathing Low blood pressure Nausea and vomiting Blurry or double vision Lightheadedness Physical weakness from relaxed muscles Abusing depressants can also lead to substance use disorders, which are influenced by genetic predisposition, environmental factors, and comorbid mental health conditions