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Association between long-term low-intensity cigarette smoking and incidence of smoking-related cancer in the national institutes of health-AARP cohort

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Unlike cigarette testing machines, which were calibrated to smoke the putative reduced-risk cigarettes in a standardised way, smokers compensated for the lower delivery of nicotine by taking more and deeper puffs per cigarette, smoking more and occluding the tiny ventilation holes on the filters with their fingers