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worse and more frequent inflammatory relapses higher likelihood of recurrence after surgery poorer response to therapy According to Crohns & Colitis UK, smoking with Crohns disease is also linked to: needing more steroids, immunosuppressants, and anti-TNF medications narrowing of the bowel (strictures), which can lead to blockage perianal disease (Crohns around the anus) bone weakness and joint problems higher risk of developing bowel cancer E-cigarettes, also called vapes, are battery-operated devices that people use to inhale an aerosol containing nicotine, flavorings, and other chemicals