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Efficacy Data: Response rate: 79% at 3 weeks (50% reduction in MADRS) Remission rate: 75% at 4 months (phase 2, open-label extension) MADRS change: -14.08 points (CYB003 16mg) vs -8.24 (placebo) at 3 weeks Time to response: 1-3 weeks Source Why it might interest you: Rapid onset, durable effect after single/few doses, minimal chronic side effects, different mechanism from standard antidepressants, no daily pill burden

We sought comment from the governments of China, Egypt and Laos

For more premium or flavored cigarette papers, expect a slight price increase

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An estimated 53,000 Americans die annually because of exposure to second-hand smoke (Glantz & Parmley, 1995)

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