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[1] The clot may fail to form because of poor blood supply (e.g., secondary to local factors such as smoking, anatomical site, bone density and conditions which cause sclerotic bone to form)

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Like Primaquine, Tafenoquine can cause hemolysis (premature red blood cell breakdown) in people with G6PD deficiency, so it shouldnt be taken by those that have the condition or by those that havent been tested for it