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In total, 34 599 cases of lung cancer in the UK (86% of the total) were due to exposure to tobacco smoke in 2010, the great majority of which (97.4%) are due to active smoking (current or in the past)

Heated tobacco products impair cell viability, osteoblastic differentiation, and bone fracture-healing

Evidence from the population-based Rotterdam study suggested that smoking was only associated with dementia risk in 4 allele non-carriers 22,23 whereas a population-based study in Finland found that smoking increased risk of dementia among 4 allele carriers 24

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