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This can happen for a variety of reasons, including tobacco that has been dropped on the floor, broken up into small pieces, discolored, dirty, tobacco dust, stems, etc

Charles father, George V, and grandfather, Edward VII, also died of smoking-related diseases, as did his granduncle Edward VIII, the Duke of Windsor

PMID 26308021

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Factors such as metabolism, body weight, and the use of several medicines might influence how caffeine affects an individual 9