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While conventional pulmonary function testing remains the cornerstone of diagnosing airflow limitation, its sensitivity for early detection of SAD is insufficient ( Physiological characteristics of the small airway Small airways are defined as those with a diameter of less than 2 mm and are considered part of the distal airway system, comprising membranous bronchioles, respiratory bronchioles, and alveolar ducts ( Initiation phase Epithelial damageEMT (epithelial-mesenchymal transition)impaired barrier functionmucus obstruction The small airway epithelium is the main defense barrier of the respiratory tract against inhaled harmful particles and pathogens

And, in turn, attracted youth

(2017, Feb 13)