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Another possible mechanism by which CS alters AHR could be due to an impact on airway smooth muscle (ASM), either the increased ability to contract [76] or the remodelling changes reported such as increased ASM thickness via antigen induced increase in proliferation/migration associated with the AHR phenotype [77]

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Previous studies have identified several molecules belonging to the TSNAs family, which are known to be carcinogenic [39,70]