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It contains the same addictive chemical, nicotine, contained in cigarettes

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In one study, an alveolar blood barrier consisting of a co-culture of epithelial lung cells on the apical compartment and endothelial cells on the basal compartment, was treated on the apical compartment with condensed e-cigarette aerosols of menthol and tobacco flavors with nicotine

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More nicotine is required to produce the same pleasurable effects that they experienced at lower doses