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Fifty-nine participants (HIV-/Smok- [ n = 16], HIV-/Smok+ [ n =14], HIV+/Smok- [ n = 18], and HIV+/Smok+ [ n = 11]) underwent baseline eligibility tests, positron emission tomography (PET) scanning to determine levels of a marker for neuroinflammation, and assessment of cognitive control with the reverse-translated 5-choice continuous performance test (5C-CPT), with smokers having smoked to satiety prior to testing

The link between smoking and metabolism When you quit smoking, your metabolism changes: When we stop smoking, our body resumes normal functioning and reaches a weight that would be the one we would have if we had never smoked

Ethyl Glucuronide (EtG) Test: EtG is a direct metabolite of ethanol (drinking alcohol)

Mice develop and age very differently to humans, and major developmental life events occur at different rates

It takes time, effort, and commitment, but the reward is a real improvement in quality of life

WHO Technical Report Series 989 Ch