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In the brain, nicotine works mostly to release other neurotransmitterslike dopamine (pleasure), norepinephrine (arousal and appetite suppression), glutamate (learning and memory), endogenous opiates, and serotonin (mood modulation)
The variation is driven by differences in smoking habits such as the type of cigarette used, the number of puffs taken and how deeply smokers inhale
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[i] Before 2024, the wording referred to regular cigarettes
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