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A 2012 study published in the scientific journal Indoor Air compared the vapor of electronic cigarettes to that of conventional tobacco smoke

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Notably, these disruptions in spermatogenesis and DNA methylation seemed not permanent and could be partially reversed upon nicotine cessation

But the idea that nicotine is working on the same circuitry as cocaine does point to why so many people have a hard time quitting tobacco, and why so many who experiment with the drug end up becoming addicted. The overlap between nicotine and cocaine effects at the D5 receptor may also offer a novel strategy for preventing or treating addiction