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Take this ad for Weyenberg Massagic shoes, published in (yep) Playboy in 1974 and submitted to Ms

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The study showed mechanistically that mtDNA released into the cytosol can bind to NLRP3, triggering its activation and the subsequent production of inflammatory cytokines like IL-1, contributing to inflammation in lung tissues (Nakahira et al., 2015) (Figure 2)

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