Since that COVID-19 exhibits unusual symptoms including GSH depletion, GPX4 inactivation, abnormal iron metabolism, and elevation of PUFA peroxidation by reactive oxygen species, it is possible that SARS-CoV-2 might cause ferroptosis in the dopaminergic neurons, which would then contribute to PD
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This may partially explain why cysteine is reported as a risk factor for cardiovascular disease in hyperlipidemic patients (Jacob et al, 1999), and why cysteine is related to several factors that take part in the cardiovascular risk profile (El Khairy et al, 1999)
Glutathione is a major determinant of bile-acid independent bile flow, and the effects of cold ischemia on biliary glutathione excretion are unknown
Pant, A., Cao, S
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