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Genetic (familial predisposition), environmental and behavioral factors (such as high salt intake, psychological stress, obesity, gut dysbiosis) are known hypertensinogenic factors (Harrison et al., 2021)

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pylori as the latter's appear as a consequence of inflammation of the mucosa (presence of neutrophil and submucosal edema), the former instead as a consequence of a direct damage of the NSAID molecule against COX enzymes, altering the hydrophobic state of the mucus, the permeability of the lining epithelium and mitochondrial machinery of the cell itself

Chronic musculoskeletal pain in chronic fatigue syndrome: recent developments and therapeutic implications