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The simple and intuitive "one unit, one button" device was designed in the UK, involving over 100 experts across five continents including scientists, engineers, designers, tobacco experts and toxicologists

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In addition to addiction, chronic nicotine use has been linked to cardiovascular, respiratory, pulmonary, and gastrointestinal disorders

The cigarette embodied the American ideal, a distillation of glamour, capitalism and excess, further testimony to the adoption by European of American dreams, according to author Alexander Stephan

1 Nortriptyline is also effective, other antidepressants not so much A Cochrane systematic review of 10 antidepressants used for smoking cessation included 64 placebo-controlled trials, measuring at least 6-month abstinence rates as primary outcomes, and monitoring biochemical markers (such as breath carbon monoxide and urinary cotinine) to verify abstinence