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Additionally, cotinine values can vary based on gender, genetics, ethnicity, pregnancy status, hydration levels, and the type of nicotine product used

While p53 exerts antioxidant effects by upregulating several antioxidant genes, such as glutathione peroxidase 1 ( Gpx1 ) and glutaredoxin 3 ( Grx3 ), or repressing the expression of dcyclooxygenase-2 ( Cox2 ) and nitric oxide synthase 2 ( Nos2 ) (61)

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