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ATRA is now widely used in preclinical and clinical studies and has shown great anticancer potential in phase II and III clinical trials in patients with various cancers [180]

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18(8) Any amount of cigarette smoking 3 months before and during pregnancy can lead to birth defects in infants Globally, about 8 million infants are born with severe congenital anomalies (also known as birth defects) in a given year