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The blood samples will be analysed for the following: Haemoglobin concentration by using HemoCue B immediately after blood collection (HemoCue, Vedbk, Denmark)

Vitamin B6 (10 mg as P5P) for enzymatic cofactor support.* Comprehensive Antioxidant Formula Supports antioxidative status, detoxification, cellular health, and immune response

PMID 19375609

Intracellular ROS production Intracellular reactive oxygen species (ROS) levels were measured in treated cells using the oxidant-sensitive probe 2,7dichlorofluorescein diacetate [H 2 DCFDA] 11

Pathological conditions and alteration in tissues microenvironment in the body exhibit distinct biochemical settings characterized by change in redox potential, pH level, hypoxia, reactive oxygen species (ROS), and various catalytic protein/enzyme overexpression

Q: Can you please clarify how Domain 4 projects will be evaluated against their requirements