Its a powerful stimulant that triggers the narrowing of blood vessels meaning even a single cigarette can restrict circulation in the short term
Hugod M, Storr-Paulsen A, Norregaard JC, Nicolini J, Larsen AB, Thulesen J
Jessen, Wade (April 29, 2000), "COUNTRY CORNER"
Current concepts of cholesterol transport and crystal formation in human bile
As the puff count increases, so does the expected duration of usage, with 12000 puffs lasting approximately 240 days for a casual vaper, 68.6 days for an average vaper, and 40 days for a heavy vaper
It also has plans to file a modified risk tobacco product application (MRTP) for its Copenhagen Snuff product with the FDA this year