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Mitochondrial dysfunction with loss of cytochrome c and changes in cellular redox status has been shown to alter TGF- signaling in fibroblasts, promoting fibrogenesis, and mitochondrial ROS can directly stimulate alveolar epithelial cell changes towards a profibrotic phenotype (Henderson and OReilly, 2021

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doi: 10.1158/1940-6207.CAPR-15-0058 116

Unlike cigarettes, there is no associated fire-risk when using IQOS

Low-smoke devices like vaporizers also help reduce smell