In brief, MDMR tests every voxel to determine if whole-brain connectivity to that voxel is more similar in individuals with similar values on an independent measure (daily cigarette consumption, cigarettes/day) than in individuals with dissimilar values
Cell Mol Life Sci 55:96107 Galmarini D, Galmarini CM, Galmarini FC (2012) Cancer chemotherapy: a critical analysis of its 60 years of history
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However, if you are an avid smoker and it is hard to withhold despite the advice, you must first educate yourself about the associated risks