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Since the first Surgeon Generals report in 1964 more than 20 million premature deaths [in the U.S] can be attributed to cigarette smoking

In some cases, degradation could potentially lead to the formation of other compounds, although the risks are considered low

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Chest 149:13021312 Remels AH, Gosker HR, Schrauwen P, Langen RC, Schols AM (2008) Peroxisome proliferator-activated receptors: a therapeutic target in COPD