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Though the incident became a defining moment in Clintons presidency, it also added a layer of intrigue to the connection between U.S

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High MDM2 levels catalyze P53 polyubiquitinationleading to its degradation via the proteasome pathwaywhereas low MDM2 levels induce multi-ubiquitylation, facilitating the nuclear export of P53 and consequently reducing its activity as a transcription factor