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N Engl J Med 382(10):903916

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It has been posed that nicotine leads to increases in dopamine levels within prefrontal regions through direct and indirect (GABA and glutamate influences) enhancement of dopaminergic activity that makes up for the lowered dopamine D1 stimulation and ensuing cognitive deficits observed in SZ (44, 67, 98)

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Younger demographics, particularly millennials and Gen Z, are increasingly turning towards online platforms for nicotine pouch purchases due to convenience, privacy, attractive promotions, and broader product variety

In comprises 30 per cent of all cancer deaths, and is responsible for killing around 46,000 Canadians each year