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Adults: Behavioral Risk Factor Surveillance System, Annals of Internal Medicine , August 28, 2016, [xii] Lindsey Stroud, Randomized Trial Finds E-Cigarettes Are a More Effective Smoking Cessation Tool than Nicotine Replacement Therapy, Research & Commentary , The Heartland Institute, February 11, 2019,

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Using a survey of young adults aged 18 to 26 recruited through an online crowd-sourcing tool, our group of researchers at the University of North Carolina School of Medicine found in a study published in PLOS ONE that cigarillo pack flavor descriptors, such as grape and sweet, and colors such as pink and purple, resulted in more favorable product perceptions among young adults

In studies of duloxetine in smoking and nonsmoking psychiatric patients (not directly related to pain relief), serum levels of the drug were lower in smokers than in nonsmokers, suggesting that tobacco smoke components induce drug-metabolizing enzymes (e.g., cytochrome P450 1A2) [108, 109]