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The structure of the business has the attributes of a shared monopoly, being controlled essentially by the six big tobacco companies, and this structure helps maintain this high profitability, for the high costs and complexities of maintaining huge leaf inventories (tobacco leaves are bought and matured in warehouses over a three-year period) inhibit even the most rapacious of outsider corporations from entering this closely held domain

These findings reinforce what has been previously reported in vitro models, providing further evidence that flavored e-cigarettes, regardless of the presence or absence of nicotine, could cause harm to users' health, especially during chronic use (Figure 2)

Zhang, Y., Chen, J

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