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Then, to prevent food from sticking, the narrowing must be stretched (widened)

This causes more difficulty to the flow of blood, and it raises pressure in the blood

The pathogenic involvement of EAT in AtCM associated with HFpEF may depend on altering ion currents and ionic fluxes, gap junction modulation, or fatty infiltration and fibrotic remodeling, all of which could be mediated by secreted mediators from EAT (309)

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However, filters had a major image problem: they were widely considered to be "sissified," the domain of women and cautious, less masculine men