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The study population comprised general adult participants aged 18 to over 50 years, with females accounting for 25 to 60% of participants

In a murine model of intratracheal LPS-induced pulmonary inflammation, treatment with adenosine or NECA (5'-N-ethylcarboxamidoadenosinenon-selective AR agonist), resulted in a decrease in inflammatory response and improvement of barrier function, as seen by decreased cell counts, Evans blue dye albumin (EBDA) extravasation, protein and cytokine levels, and reduced neutrophil infiltration

As well as the discolouration, smoking can thin the skin as well as dry it out due to reducing vitamin A levels and moisture