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Approximately half of high school seniors who smoked reported that they expect not to be smoking five years from the time of the survey (19761984), but 80% of those who smoked more than a half-pack per day were still smoking at follow-up (CDC, 1994)

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Therefore, lung-derived cytokines may well be the prime explanation of the higher TNF-, IL-2, IL-4, IL-6 and IL-10 concentrations and the lower level of the anti-inflammatory IL-12p70 concentration in smokers than non-smokers, indicating that even young-adult asymptomatic smokers suffer from a low-grade systemic inflammation