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We included studies in this meta-analysis that: (1) assessed gray matter using structural MRI, (2) reported a set of coordinates (i.e., foci) from a between-subjects contrast comparing smokers to matched nonsmoking participants, (3) reported coordinates in a defined stereotaxic space (i.e., Talairach or Montreal Neurological Institute [MNI]), (4) performed a whole-brain analysis, and (5) provided sufficient information regarding characterization of smoking behaviors (e.g., pack-years, Fagerstrm Test of Nicotine Dependence [FTND] scores, years smoking, number of cigarettes smoked per day), basic demographics of the study samples (e.g., age, sex, N ), and data analysis strategies (e.g., smoothing parameters, statistical thresholds)

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Gastrointestinal Problems : Including defects in the intestines and abdominal wall

That said, there were still a few disadvantages to the study

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