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Green, FDA Regulation of Tobacco Products, Congressional Research Service, updated Feb

Pooled analyses of short-term placebo-controlled trials of antidepressant drugs (selective serotonin reuptake inhibitors [SSRIs] and others) show that these drugs increase the risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (ages 18 to 24) with MDD and other psychiatric disorders

It was thought that this would increase nicotine absorption, which is inhibited in acidic media

Reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out

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p=0.246), suggesting that long-term outcomes may be influenced by factors outside the programs scope, such as intrinsic motivation or social environment