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Weve been trying to do a tour forever, since 2017, Gonzalez adds

Lower-intensity smoking is associated with cardiovascular risk and the primary public health message for current smokers should be early cessation, rather than reducing the amount of smoking, the study authors wrote

Public Health 28, 225228.10.1111/j.1467-842X.2004.tb00700.x 41 GroveK

Regulators, meanwhile, should take note of the significant health risks now clearly associated with these products

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The target sample size was 636, based on power analysis for the primary research question using G*Power, with 90% power to determine an effect size (f2) of 0.02 on our primary outcome at an alpha level of 0.05