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For acute 5-HT 1A R antagonist studies, rats were given a single infusion of WAY-100,635 (100 g/kg, i.v.), S-15535 (300 g/kg, i.v.), or vehicle 20 min prior to locomotor testing

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The report states: '[It is] clear that tobacco products and cigarettes in particular are highly engineered to expand the appeal of these products and facilitate the consumption of and addiction to nicotine, a highly addictive drug

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