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Population stratification bias was reduced in this study because SNP selection and summary-level data of psychiatric disorders were merely based on individuals of European descent and population structure was adjusted for in the GWASs

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However, there still may be some bias (toward a positive association) from including all smoking status groups in the same model, especially if there is an unaccounted-for interactive effect between EC use and smoking history (such that those with longer smoking histories have higher health risks) which could falsely appear to carry over to PWNS

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Relative value of inflammatory, hemostatic, and rheological factors for incident myocardial infarction and stroke: the Edinburgh Artery Study