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Furthermore, clinical trials have shown that standard NRT doses are inadequate for rapid metabolizers of nicotine (i.e., those who inactivate nicotine to cotinine and then to 3-hydroxycotinine [3-HC] more quickly than others due to genetic variation affecting the activity of the hepatic enzyme CYP2A6) [20, 25]

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Worms and their eggs also excrete proteins that exacerbate this chronic inflammation, further promoting cell division as well as the blood vessel growth required to feed it, adds Richter

(2014) 23:iii39