Diabetes 59 , 600610 (2010)
In 1998, Andrew Fire and Craig Mello reported that double-stranded RNA (dsRNA) had potent gene silencing effects in Caenorhabditis elegans , 38 a discovery they termed RNA interference (RNAi)
They also reported that these patients had higher levels of interleukin 1 (IL-1), IL-6, and TNF- , suggesting an inflammatory state and oxidative stress in migraine patients (112)
His colleague Shin-ichiro Imai, a professor of developmental biology at the Washington University School of Medicine who first met Sinclair in Guarentes lab, says Sinclair had a keen eye for capturing novel concepts and, based on that foundation, building new lines of research faster than anyone else. At the time, aging research, once considered a fringe science, was still in its infancy, but Sinclair was determined to propel it to legitimacy
Unlike the GPX4 pathway, this pathway affects the levels of peroxyl radicals on the membrane, thereby inhibiting lipid peroxidation (Kraft et al., 2020)
Clin Endocrinol (Oxf) (2013) 78:15564
