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We developed a murine adolescent smoking model before conception to investigate the paternal molecular causes of changes in offsprings phenotype

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Even though medication can help make these feelings less uncomfortable, people trying to quit still may encounter times when it is hard to quit or when they really wish they could just smoke. Distress tolerance is an important factor to examine because if someone often uses smoking as a coping device, when they attempt to quit smoking, they are forced to either tolerate the distress or find a different way to cope

These lessons learned from the present study could inform a more efficient RCT