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As the articles on Nat Turners slave rebellion in 1831, the Dred Scott case in 1857, the Civil Rights amendments of the 1860s, and the attempt at replacing plantation oligarchy with republican regimes in the states after the Civil War all show, natural rights have been the pivot of struggles over the character of America

Individuals develop MS when their immune system starts According to a 2022 paper, tobacco smoking is a risk factor for more serious forms of MS

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One limitation is the stiff penalty for multiple comparisons leading to the need for increasingly large sample sizes