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Post-Quit Depression: Causes and Symptoms Post-quit depression refers to the development of depressive symptoms after quitting smoking

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Most people who are finding it tough to quit will start smoking again in the first 3 months after trying to quit

Jackson SE, Shahab L, Buss V, Tattan-Birch H, Cox S, Taylor E, Brown J

This is in agreement with emerging evidences suggesting that VE-cadherin controls claudin-5 expression by preventing the nuclear accumulation of FoxO1 and beta-catenin which repress the claudin-5 promoter [47] thus reducing its expression