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Because it has an autoregulatory negative feedback loop between p53 and MDM2, toxicant-induced p53 overactivation might enhance MDM2 expression, and thereby promote Akt phosphorylation and inhibit Pim phosphorylation in hepatocytes, which contributed hepatocytes to survival in toxicant-induced hepatic inflammation 26

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The database used was the Clarivate Analytics Web of Science (WoS) core collection and PudMed/MEDLINE

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