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Effect of a Topical Collagen Tripeptide on Antiaging and Inhibition of Glycation of the Skin: A Pilot Study

Ang II elevates catecholamines in the periphery and central, and pretreatment with Ang II receptor antagonism losartan significantly attenuates neuroendocrine responses, indicating Ang II activates sympathetic-adrenomedullary system activity through AT1R during stress (180)

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However, a high daily dose of ASX (30 mg/kg) should be applied over an extended period to achieve neuroprotective effects because of the limited bioavailability of free ASX, which is closely related to its low solubility in water [13, 14]

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The lyophilized vials most users handle are research-grade