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How doctors can test for nicotine Nicotine and its byproduct cotinine can be detected through several types of tests, each with its own detection window: Urine tests are the most common, often detecting nicotine use within the past three to four days and up to three weeks in heavy users, according to Verywell Mind

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Increased Appetite: Many individuals experience an increase in appetite and food cravings during tobacco withdrawal

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Heavy or prolonged vaping can lead to higher levels of cotinine in the blood, which may persist for several days or even up to a week