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Accessed June 21, 2021

Abbreviations ACPA: anti-citrullinated protein antibody AM: alveolar macrophage CCP: cyclic citrullinated peptide EBV: EpsteinBarr virus HLA: human leukocyte antigen IFN: interferon IL: interleukin LPS: lipopolysaccharide NARAC: North American Rheumatoid Arthritis Consortium NF: nuclear factor PAD: peptidyl arginine deiminase PTPN22: protein tyrosine phosphatase nonreceptor 22 RA: rheumatoid arthritis RF: rheumatoid factor SE: shared epitope siRNA: small interfering RNA SONORA: Study of New Onset Rheumatoid Arthritis TNF: tumor necrosis factor

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