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Demand is steadily increasing due to rising global smoking rates, combined with an evolving regulatory environment

BMJ 372 , n71 (2021)

Ther Adv Chronic Dis 6 FarsalinosK.NiauraR.LeHouezec JBarbouniA.TsatsakisA.KouretasD.et al (2020b)

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Early development of stricturing or penetrating pattern in Crohns disease is influenced by disease location, number of flares, and smoking but not by NOD2/CARD15 genotype