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When nicotine is taken regularly, the brain builds up a tolerance to the levels of dopamine being produced, eventually becoming unable to produce the same levels on its own

Neurosci Biobehav Rev 46 (Pt 3), 397406, (2014)

Archived from the original on July 11, 2011

For this reason, there are theories including lean body and muscle weight related to cardiovascular accidents that are not properly reflected in the body weight and obesity paradox ( It is well known from previous studies that smoking contributes to an increased cardiovascular risk

Surgeon General warning statements that have been required on the side of cigarette packs since 1985