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These studies also vary in their risk definitions, with many comparing dichotomous exposure measures of ever smokers versus nonsmokers 19,20

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There is growing evidence through the use of animal xenograft models and cell culture systems, that (1) nicotine's carcinogenic role stems from multiple signaling mechanisms, primarily involving both non-receptor-mediated actions and receptor-mediated effects, including nicotinic acetylcholine receptors, -adrenergic receptors and epidermal growth factor receptors, as well as transforming growth factor receptors

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Retrieved February 21, 2006

So what about the time-tested strategy of simply raising cigarette taxes some more